{"id":2673,"date":"2025-10-25T15:18:26","date_gmt":"2025-10-25T08:18:26","guid":{"rendered":"https:\/\/museum.pctu.com.vn\/?p=2673"},"modified":"2025-12-12T10:38:37","modified_gmt":"2025-12-12T03:38:37","slug":"the-worlds-first-pig-heart-transplant","status":"publish","type":"post","link":"https:\/\/museum.pctu.com.vn\/index.php\/language\/en\/2025\/10\/25\/the-worlds-first-pig-heart-transplant\/","title":{"rendered":"The World\u2019s First Pig-Heart Transplant"},"content":{"rendered":"<p style=\"text-align: justify;\" data-start=\"62\" data-end=\"307\">The surgery performed on <strong data-start=\"87\" data-end=\"106\">January 7, 2022<\/strong> marked the first time in history that a pig organ was transplanted into a human.<br data-start=\"187\" data-end=\"190\" \/>The patient, who received a <strong data-start=\"218\" data-end=\"243\">gene-edited pig heart<\/strong>, survived the operation and initially showed signs of recovery.<\/p>\n<p style=\"text-align: justify;\" data-start=\"309\" data-end=\"587\">Prior to this live human surgery, in 2021, surgeons at <strong data-start=\"364\" data-end=\"386\">NYU Langone Health<\/strong> in New York tested gene-edited pig kidney transplants on two brain-dead individuals. The transplanted kidneys were not rejected and functioned normally while the bodies were maintained on ventilators.<\/p>\n<p style=\"text-align: justify;\" data-start=\"589\" data-end=\"910\">Most research in xenotransplantation had previously been conducted on primates. However, scientists hope that this successful gene-edited pig heart transplant will serve as an important step toward clinical trials of animal-to-human organ transplantation, helping to overcome longstanding scientific and ethical barriers.<\/p>\n<p style=\"text-align: justify;\" data-start=\"912\" data-end=\"1443\">Researchers had submitted an application to the <strong data-start=\"960\" data-end=\"1003\">U.S. Food and Drug Administration (FDA)<\/strong> to begin clinical trials of pig-to-human heart transplantation, but the request was denied.<br data-start=\"1095\" data-end=\"1098\" \/>According to <strong data-start=\"1111\" data-end=\"1137\">Dr. Muhammad Mohiuddin<\/strong>, lead surgeon of the xenotransplantation program at the University of Maryland, the FDA was initially concerned about ensuring that donor pigs were sourced from certified medical-grade facilities and recommended that the team perform <strong data-start=\"1372\" data-end=\"1410\">10 pig-to-baboon heart transplants<\/strong> before moving to human subjects.<\/p>\n<p style=\"text-align: justify;\" data-start=\"1445\" data-end=\"1777\">However, <strong data-start=\"1454\" data-end=\"1483\">57-year-old David Bennett<\/strong> gave Mohiuddin\u2019s team an exceptional opportunity. Bennett had depended on a heart-lung bypass machine for nearly two months and could no longer sustain circulation due to severe arrhythmias. He was also not eligible for a human donor heart because of past noncompliance with medical treatment.<\/p>\n<p style=\"text-align: justify;\" data-start=\"1779\" data-end=\"2050\">Given the life-threatening condition of the patient, the FDA granted emergency authorization for the team to transplant the gene-edited pig heart into Bennett.<br data-start=\"1938\" data-end=\"1941\" \/>The surgery proceeded smoothly, and the transplanted heart functioned well afterward, Dr. Mohiuddin reported.<\/p>\n<p style=\"text-align: justify;\" data-start=\"2052\" data-end=\"2334\">The surgical team monitored Bennett\u2019s immune response and heart function closely.<br data-start=\"2133\" data-end=\"2136\" \/>Dr. Mohiuddin stated that the research team would continue controlled clinical trials and may seek approval for additional xenotransplant procedures for patients in urgent need of organ replacement.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The surgery performed on January 7, 2022 marked the first time in history that a pig organ was transplanted into a human.The patient, who received a gene-edited pig heart, survived&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73,47],"tags":[],"class_list":["post-2673","post","type-post","status-publish","format-standard","hentry","category-global-healthcare","category-uncategorized-en"],"_links":{"self":[{"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/2673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/comments?post=2673"}],"version-history":[{"count":1,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/2673\/revisions"}],"predecessor-version":[{"id":2674,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/posts\/2673\/revisions\/2674"}],"wp:attachment":[{"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/media?parent=2673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/categories?post=2673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/museum.pctu.com.vn\/index.php\/wp-json\/wp\/v2\/tags?post=2673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}